Open AccessAntagonist of C5aR Prevents Cardiac Remodeling in Angiotensin II-Induced Hypertension
Author(s) -
C Zhang,
Yan Li,
Chunxiao Wang,
Yafeng Wu,
Jie Du
Publication year - 2014
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpt274
Subject(s) - medicine , antagonist , angiotensin ii , cardiology , angiotensin ii receptor antagonist , blood pressure , angiotensin receptor , receptor
Inflammatory responses mediate the development of perivascular fibrosis and heart dysfunction induced by hypertension. Complement is an important inflammatory system, and we aimed to evaluate the effect of a specific C5a receptor antagonist (C5aRA), PMX53, on inflammation and perivascular fibrosis in the hypertensive heart of the mouse.
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