Open AccessAmlodipine Increased Endothelial Nitric Oxide and Decreased Nitroxidative Stress Disproportionately to Blood Pressure Changes
Author(s) -
Ronald P. Mason,
Robert F. Jacob,
J. Jose Corbalan,
Roman Kaliszan,
Tadeusz Maliñski
Publication year - 2013
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpt202
Subject(s) - amlodipine , medicine , blood pressure , nitric oxide , endothelial dysfunction , enos , peroxynitrite , mean arterial pressure , vasodilation , endocrinology , heart rate , nitric oxide synthase , chemistry , superoxide , biochemistry , enzyme
Clinical trials have shown that amlodipine reduces cardiovascular events at a rate that is not predicted by changes in brachial arterial pressure alone. These findings may be explained, in part, by the pleiotropic effects of amlodipine on endothelial cell (EC) function. In this study, we elucidated the effect of amlodipine on nitric oxide (NO) bioavailability and cytotoxic peroxynitrite (ONOO(-)) and blood pressure (BP).
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