Open AccessRenal Nitric Oxide Synthase and Antioxidant Preservation in Cyp1a1-Ren-2 Transgenic Rats With Inducible Malignant Hypertension
Author(s) -
Mark Cunningham,
Jennifer M. Sasser,
Crystal A. West,
Carlo Milani,
Chris Baylis,
Kenneth D. Mitchell
Publication year - 2013
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpt096
Subject(s) - medicine , nitric oxide synthase , nitric oxide , antioxidant , pharmacology , oxidative stress , transgene , atp synthase , endocrinology , enzyme , biochemistry , biology , gene
Dietary administration of 0.30% indole-3-carbinol (I3C) to Cyp1a1-Ren2 transgenic rats (TGRs) generates angiotensin II (ANG II)-dependent malignant hypertension (HTN) and increased renal vascular resistance. However, TGRs with HTN maintain a normal or slightly reduced glomerular filtration rate. We tested the hypothesis that maintenance of renal function in hypertensive Cyp1a1-Ren2 TGRs is due to preservation of the intrarenal nitric oxide (NO) and antioxidant systems.
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