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Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE.

Impact of Spironolactone on Vascular, Myocardial, and Functional Parameters in Untreated Patients With a Hypertensive Response to Exercise