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Pre-eclampsia (PE) is associated with vascular endothelial dysfunction and oxidative stress initiated by impaired trophoblast invasion. Oxidative stress modifies circulating low-density lipoprotein (LDL) to oxidized LDL (oxLDL). Lectin-like oxLDL receptor-1 (LOX-1) is a scavenger receptor for oxLDL. We hypothesized that plasma from patients with PE alters LOX-1 in normal human vessels during pregnancy, causing oxLDL-induced impairment of vascular function.

american journal of hypertension

Inhibition of Lectin-Like Oxidized Low-Density Lipoprotein-1 Receptor Protects Against Plasma-Mediated Vascular Dysfunction Associated With Pre-Eclampsia