English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The author addresses issues related to interpretation of the parameters in the proposed case-only linear regression approach to testing for gene-environment interaction recently considered by Clarke and Morris (Am J Epidemiol. 2010;171(4):498-505). He also considers the robustness of their likelihood ratio test to violation of the assumption of Gaussian regression residuals under the null hypothesis of no interaction; shows how their approach can be extended to a more general class of regression models; and derives the optimal interaction test statistic for this class of regression models. Finally, the author briefly discusses case-only doubly robust methods recently proposed by Tchetgen Tchetgen and Robins (Biometrics. 2010;Mar 11).

On the Interpretation, Robustness, and Power of Varieties of Case-Only Tests of Gene-Environment Interaction