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Objectives Peripheral blood flow cytometry (PBFC) is useful for evaluating circulating hematologic malignancies (HM) but has limited diagnostic value for screening. We used machine learning to evaluate whether clinical history and CBC/differential parameters could improve PBFC utilization. Methods PBFC cases with concurrent/recent CBC/differential were split into training (n = 626) and test (n = 159) cohorts. We classified PBFC results with abnormal blast/lymphoid populations as positive and used two models to predict results. Results Positive PBFC results were seen in 58% and 21% of training cases with and without prior HM (P &amp;lt; .001). % neutrophils, absolute lymphocyte count, and % blasts/other cells differed significantly between positive and negative PBFC groups (areas under the curve [AUC] &amp;gt; 0.7). Among test cases, a decision tree model achieved 98% sensitivity and 65% specificity (AUC = 0.906). A logistic regression model achieved 100% sensitivity and 54% specificity (AUC = 0.919). Conclusions We outline machine learning-based triaging strategies to decrease unnecessary utilization of PBFC by 35% to 40%.

Machine Learning Models Improve the Diagnostic Yield of Peripheral Blood Flow Cytometry