Open AccessFADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
Author(s) -
Nicola Martinelli,
Domenico Girelli,
Giovanni Malerba,
Patrizia Guarini,
Thomas Illig,
Elisabetta Trabetti,
Marco Sandri,
Simonetta Friso,
Francesca Pizzolo,
Linda Schaeffer,
Joachim Heinrich,
Pier Franco Pignatti,
Roberto Corrocher,
Oliviero Olivieri
Publication year - 2008
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/88.4.941
Subject(s) - fads2 , fatty acid desaturase , eicosapentaenoic acid , linoleic acid , polyunsaturated fatty acid , single nucleotide polymorphism , arachidonic acid , coronary artery disease , medicine , odds ratio , biology , haplotype , endocrinology , genotype , fatty acid , biochemistry , docosahexaenoic acid , gene , enzyme
The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA). Single-nucleotide polymorphisms (SNPs) in FADS1 and FADS2 have been associated with different concentrations of AA and LA, and those associations have possible functional consequences for desaturase activity.
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