Open AccessLymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans 1–3
Author(s) -
Shawna L. Stratton,
Anna Bogusiewicz,
Matthew M Mock,
Nell I. Mock,
Amanda M Wells,
Donald M. Mock
Publication year - 2006
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/84.1.384
Subject(s) - biotin , biotin deficiency , pyruvate carboxylase , endocrinology , medicine , acetyl coa carboxylase , biochemistry , biology , enzyme
Marginal biotin deficiency may be a human teratogen. A biotin status indicator that is not dependent on renal function may be useful in studies of biotin status during pregnancy. A previous study of experimental biotin deficiency suggested that propionyl-coenzyme A carboxylase (PCC) activity in peripheral blood lymphocytes (PBLs) is a sensitive indicator of biotin status.
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