Open AccessHigh prevalence of hyperhomocysteinemia related to folate deficiency and the 677C→T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa
Author(s) -
Emile Amouzou,
Nicodème Chabi,
Charles Adjalla,
Rosa María Rodríguez-Guéant,
François Feillet,
C. Villaume,
Ambaliou Sanni,
JeanLouis Guéant
Publication year - 2004
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/79.4.619
Subject(s) - methylenetetrahydrofolate reductase , hyperhomocysteinemia , genetics , gene , mutation , medicine , reductase , folic acid , biology , homocysteine , genotype , enzyme , biochemistry
Moderate hyperhomocysteinemia is a risk for neural tube defect and neurodegenerative and vascular diseases and has nutritional, metabolic, and genetic determinants. Its prevalence in sub-Saharan Africa remains unknown.
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