Open AccessMethylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial,,
Author(s) -
Pauline AshfieldWatt,
Catherine H Pullin,
Jane M. Whiting,
Zoë Clark,
Stuart J. Moat,
Robert G. Newcombe,
M L Burr,
Malcolm Lewis,
Hilary J. Powers,
I.F.W. McDowell
Publication year - 2002
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/76.1.180
Subject(s) - methylenetetrahydrofolate reductase , homocysteine , medicine , endocrinology , ingestion , placebo , folic acid , genotype , chemistry , biochemistry , alternative medicine , pathology , gene
Low folate status and elevated plasma homocysteine are associated with increased risk of neural tube defects and cardiovascular disease. Homocysteine responses to folate may be influenced by genetic variants in folate metabolism.
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