Open AccessEffects of acute (−)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans
Author(s) -
Luc J. C. van Loon,
Johannes JM van Rooijen,
Bas Niesen,
Hans Verhagen,
Wim H. M. Saris,
Anton J. M. Wagenmakers
Publication year - 2000
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.1093/ajcn/72.6.1445
Subject(s) - ingestion , placebo , chemistry , medicine , endocrinology , vo2 max , metabolism , exercise physiology , carbohydrate , carbohydrate metabolism , beta oxidation , zoology , biochemistry , biology , heart rate , blood pressure , alternative medicine , pathology
(-)-Hydroxycitrate (HCA), a competitive inhibitor of ATP-citrate lyase, should reduce the extramitochondrial acetyl-CoA pool. It has been hypothesized that HCA ingestion can reduce malonyl-CoA concentrations and consequently increase fatty acid oxidation in vivo.
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