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Tight junctions (TJs) are composed of claudin-based TJ strands. The complexity of TJ strands regulates paracellular permeability of epithelial cells. Occludin and tricellulin contribute to the formation of the complex TJ-strand network possibly by connecting TJ strands and establishment of a tight barrier.

Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function