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This study reports that the actin-binding protein, LIM and SH3 Protein 1 (LASP1), regulates actin-based protrusions underlying axon elongation and branching in hippocampal neurons in culture. LASP1 also plays an important role in axon development in vivo, as loss of the Drosophila homologue LASP disrupts the commissural axon development.

LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development