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HEXIM1 is often down-regulated in human triple-negative breast cancer (TNBC), and these cancer cells are highly sensitive to Hsp90 inhibitors. However, the mechanistic link between the two has not been determined. Our study provides a mechanistic explanation for the increased sensitivity of TNBC to Hsp90 inhibition.

HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer