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OSBPL1 encodes the full-length ORP1L and the truncated variant ORP1S. ORP1S is responsible for transferring cholesterol from late endosomes to the plasma membrane to regulate cholesterol efflux by ABCA1 and LDL receptor activity. ORP1L and ORP1S combine to transport cholesterol from late endosomes to the ER and PM, respectively.

Oxysterol-binding protein-related protein 1 variants have opposing cholesterol transport activities from the endolysosomes