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SPOP is a substrate recognition receptor of the CUL3 ubiquitin E3 complex and is point mutated in 10–15% of prostate cancer patients. Here, it is shown that, in prostate cancer cells, SPOP is involved in the DNA-protein cross-link repair process through the elimination of TOP2A from the TOP2A-DNA complex, which may prevent the genome instability.

molecular biology of the cell

SPOP is essential for DNA–protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex