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Who would have thought that the motor domain of a motor was dispensable? Nonmuscle myosin II has long been implicated in providing the contractile force to constrict the actomyosin ring during cytokinesis. So it was quite a shock to learn that myosin II could promote ring assembly and constriction (albeit a bit more slowly than wild-type) without its motor-domain “head” in budding yeast! The key finding here was serendipitous and illustrates the importance of good controls: the intent was to investigate structure–function relationships among different myosins, and the big surprise came from analysis of the “headless” control (Lord et al., 2005). Subsequent work from other labs showed the myosin tail helps IQGAP to assemble the actin ring, and the force for ring constriction comes from inward squeezing by extracellular wall components, including chitin.

An MBoC Favorite: Cytokinesis depends on the motor domains of myosin-II in fission yeast but not in budding yeast