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We prove sign-alternation of the structure constants in the basis of structure sheaves of opposite Schubert varieties in the torus-equivariant Grothendieck group of coherent sheaves on the flag varieties $G/P$ associated to an arbitrary symmetrizable Kac-Moody group $G$, where $P$ is any parabolic subgroup. This generalizes the work of Anderson-Griffeth-Miller from the finite case to the general Kac-Moody case, and affirmatively answers a conjecture of Lam-Schilling-Shimozono regarding the signs of the structure constants in the case of the affine Grassmannian.

Positivity in 𝑇-equivariant 𝐾-theory of flag varieties associated to Kac-Moody groups II