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The issue of whether radiation-induced thyroid cancer is pathologically different from sporadic remains not fully answered. This study compared structural characteristics and invasive features of papillary thyroid carcinoma (PTC) in two age-matched groups: patients who were children (≤4 years old) at the time of the Chernobyl accident and who lived in three regions of Ukraine most contaminated by radioactive iodine 131 I ("radiogenic" cancer), and those who lived in the same regions but who were born after 1987 and were not exposed to 131 I ("sporadic" cancer). Further, the histopathologic features of PTC were analyzed in relation to age and individual 131 I thyroid dose.

Comparative Histopathologic Analysis of “Radiogenic” and “Sporadic” Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident