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Multiple endocrine neoplasia type 2 is an autosomal dominant inherited syndrome caused by activating mutations in the RET proto-oncogene. The RET K666N DNA variant was previously reported in two isolated medullary thyroid carcinoma (MTC) cases, but no family studies are available, and its oncogenic significance remains unknown.

Medullary Thyroid Carcinoma Associated with Germline RETK666N Mutation

Medullary Thyroid Carcinoma Associated with Germline RET^K666N Mutation