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The X-linked inhibitor of apoptosis protein (XIAP) is associated with carcinogenesis, cancer progression, and metastasis through inhibition of the caspase-mediated apoptotic pathway. The BRAF(V600E) mutation is the most common genetic alteration and an established prognostic marker in papillary thyroid cancer (PTC). The prevalence of the BRAF mutation is very high and is up to 80% in Korean PTC patients. In the present study, we evaluated the potential role of XIAP expression as a novel prognostic marker to predict recurrence, in combination with the BRAF(V600E) mutational status.

thyroid

Association Between Expression of X-Linked Inhibitor of Apoptosis Protein and the Clinical Outcome in a <i>BRAF<sup>V600E</sup></i>-Prevalent Papillary Thyroid Cancer Population

Association Between Expression of X-Linked Inhibitor of Apoptosis Protein and the Clinical Outcome in a BRAFV600E-Prevalent Papillary Thyroid Cancer Population

Association Between Expression of X-Linked Inhibitor of Apoptosis Protein and the Clinical Outcome in a BRAF^V600E-Prevalent Papillary Thyroid Cancer Population