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Gonadotropin receptors, unlike the thyrotropin receptor (TSHR), are not cleaved into disulfide-linked A- and B-subunits, nor do they shed A-subunits. Heavily glycosylated TSHR A-subunits initiate or amplify responses leading to stimulating TSHR-autoantibodies and Graves' hyperthyroidism.

thyroid

An Attempt to Induce “Graves' Disease of the Gonads” by Immunizing Mice with the Luteinizing Hormone Receptor Provides Insight into Breaking Tolerance to Self-Antigens