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Orthosteric cannabinoid receptor 1 (CB 1 ) activation leads to decreases in intraocular pressure (IOP). However, use of orthosteric CB 1 agonists chronically has several disadvantages, limiting their usefulness as clinically relevant drugs. Allosteric modulators interact with topographically distinct sites to orthosteric ligands and may be useful to circumvent some of these disadvantages. The purpose of this study was to investigate the effects of the novel CB 1 -positive allosteric modulator (PAM) GAT229 on IOP.

journal of ocular pharmacology and therapeutics

The<i>In Vivo</i>Effects of the CB<sub>1</sub>-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice

TheIn VivoEffects of the CB1-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice

TheIn VivoEffects of the CB₁-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice