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Loxapine, a first-generation antipsychotic, delivered with a novel inhalation delivery device developed for the acute treatment of agitation in patients with schizophrenia or bipolar disorder was evaluated in subjects with asthma or chronic obstructive pulmonary disease (COPD).

Safety and Tolerability of Inhaled Loxapine in Subjects with Asthma and Chronic Obstructive Pulmonary Disease—Two Randomized Controlled Trials