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Aim:  To evaluate the performance of Madras Diabetes Research Foundation-Indian Diabetes Risk Score (MDRF-IDRS) in different ethnic groups, including Indians, Hispanic, non-Hispanic whites, non-Hispanic blacks, and other American.  Methods:  The MDRF-IDRS is calculated based on a risk equation that includes age, waist circumference, family history of diabetes, and physical activity. The National Health and Nutrition Examination Survey data on American and Chennai Urban Rural Epidemiology Study data on Indians were used in this study. Study participants aged ≥20 years with and without type 2 diabetes were included. Performance of the MDRF-IDRS was assessed using sensitivity, specificity, positive predictive value, negative predictive value, and the area under the receiver operating characteristic curve (AUC) measures within each ethnic group. IDRSs' performance was then compared with existing noninvasive American diabetes risk scores.  Results:  Total number of participants included was 11,035 (2292 Indians and 8743 Americans). MDRF-IDRS (cutoff ≥60) performed well in Indians with an AUC, sensitivity, and specificity of 0.73, 80.2%, and 57.3%, respectively. MDRF-IDRS cutoff ≥70 had the highest discriminative performance among Hispanic, non-Hispanic whites, and non-Hispanic blacks with sensitivity and specificity of between 70.1%-86.9% and 61.2%-72.2%, respectively. The AUC for American was between 0.77 and 0.81 with the highest and lowest AUC in non-Hispanic black and non-Hispanic white, respectively. With a smaller number of variables, IDRS showed almost the same performance in predicting diabetes among American compared with the existing noninvasive American diabetes risk score.  Conclusion:  The MDRF-IDRS performs well among Indians and Americans, including Hispanic, non-Hispanic white, non-Hispanic black, and other American. It can be used as a screening tool to help in early diagnosis, management, and optimal control of diabetes mainly in mass screening programs in India and America.

Evaluating the Performance of the Indian Diabetes Risk Score in Different Ethnic Groups