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A noninvasive method of monitoring the loss of islet cells can provide an earlier and improved diagnosis for therapeutics development of preclinical phases of diabetes. The use of [(18)F]fallypride, a dopamine D2/D3 receptor radiotracer, has been developed as a surrogate marker to evaluate loss of pancreatic islet cells in a rodent model of type 1 diabetes.

Imaging Pancreas in Healthy and Diabetic Rodent Model Using [18F]Fallypride Positron Emission Tomography/Computed Tomography

Imaging Pancreas in Healthy and Diabetic Rodent Model Using [¹⁸F]Fallypride Positron Emission Tomography/Computed Tomography