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Glucose tolerance can be assessed noninvasively using (13)C-labeled glucose added to a standard oral glucose load, by measuring isotope-enriched CO(2) in exhaled air. In addition to the clear advantage of the noninvasive measurements, this approach may be of value in overcoming the high variability in blood glucose determination.

Intra-Individual Variability of CO2 Breath Isotope Enrichment Compared to Blood Glucose in the Oral Glucose Tolerance Test

Intra-Individual Variability of CO₂ Breath Isotope Enrichment Compared to Blood Glucose in the Oral Glucose Tolerance Test