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(68)Ga-NODAGA-THERANOST™ is an αvβ3 integrin antagonist and the first radiolabeled peptidomimetic to reach clinical development for targeting integrin receptors. In this first-in-human study, the feasibility of integrin receptor peptidomimetic positron emission tomography/computed tomography (PET/CT) imaging was confirmed in patients with non-small-cell lung cancer and breast cancer.

cancer biotherapy and radiopharmaceuticals

First-In-Human Study Demonstrating Tumor-Angiogenesis by PET/CT Imaging with68Ga-NODAGA-THERANOST, a High-Affinity Peptidomimetic for αvβ3Integrin Receptor Targeting