English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Interhemispheric communication plays a critical role to ensure normal brain functions in cognition and behavior. Since non-human primate (NHP) brains resemble most aspects of the human brain, a thorough knowledge of interhemispheric cortical connectivity changes in NHP brains throughout the developmental and aging periods may provide valuable insights for translational and clinical research. In this study, formalin-fixed rhesus monkey brains aged from 1 to 24 years were utilized to examine transcallosal connectivity changes using diffusion spectrum imaging (DSI). It was found that the transcallosal connectivity for most frontal cortical areas, including dorso- and ventro-lateral prefrontal, premotor, and motor cortices, demonstrated pronounced age-related alterations. However, such a pattern was less obvious in temporal, posterior parietal, and visual cortices. The DSI results reveal the age-related evolution pattern of transcallosal connectivity in various cortical areas of macaque brains from infancy to late adulthood, and may have implications for assessing the functional defects or alterations in the associated cortical areas during brain development and aging in humans.

Transcallosal Connectivity Changes from Infancy to Late Adulthood: An Ex Vivo Diffusion Spectrum Imaging Study of Macaque Brains