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Glycating stress can occur together with oxidative stress during neurodegeneration and contribute to the pathogenic mechanism. Nerve growth factor (NGF) accumulates in several neurodegenerative diseases. Besides promoting survival, NGF can paradoxically induce cell death by signaling through the p75 neurotrophin receptor (p75 NTR ). The ability of NGF to induce cell death is increased by nitration of its tyrosine residues under conditions associated with increased peroxynitrite formation.

Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75NTRand RAGE Signaling in ALS

Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75^NTRand RAGE Signaling in ALS