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Activation of intrarenal renin-angiotensin system (RAS) has a detrimental effect on the progression of chronic kidney diseases (CKDs), although the regulation of intrarenal RAS remains unclear. The aim of the present study was to evaluate the role of advanced oxidation protein products (AOPPs) in intrarenal RAS activation.

Advanced Oxidation Protein Products Activate Intrarenal Renin–Angiotensin Systemviaa CD36-Mediated, Redox-Dependent Pathway