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Changes in our society such as the increasing cost of retirement and age redistribution toward a larger elderly population will require humans to remain highly functional until an advanced age. As a consequence, chronic illnesses that are primarily responsible for reducing functionality and life expectancy will require improved prevention and therapeutic strategies. In a global way, cardiovascular disease and cancer represent the most challenging disorders to maintaining the functional integrity of our fellow humans. A new theory has been derived from recent progress in our understanding of atherosclerosis as a key mechanism for cardiovascular disease and of cancer. Instructively, this theory provides a bridge at the stem cell level, linking most chronic disorders.

Jay and Jeanie Schottenstein Prize in Cardiovascular Science: Predicting Cardiovascular Illnesses for the 21st Century, and the Unpredictable …