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The U.S. Food and Drug Administration has regulatory authority over tobacco products, including conventional cigarettes and next generation products (NGPs) such as e-cigarettes and tobacco heating products (THPs). There is a desire by the industry, regulator and animal, protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment. When assessing respiratory effects in vitro, reliable exposure systems that deliver aerosols to cellular/tissue cultures (such as human reconstructed airways or lung slices) at the air–liquid interface are needed. Using nicotine dosimetry, we report the characterization of a Vitrocell VC1 in our laboratories (IIVS, USA). Nicotine, generated from a 3R4F reference cigarette or NGP (e-cigarette and THP) aerosols at source and the exposure interface (culture media), was assessed using ultra-high-performance liquid chromatography–tandem mass spectrometry. These data were compared to published dosimetry data for the same products, gen...

applied in vitro toxicology

Characterization of a Vitrocell VC1 Using Nicotine Dosimetry: An Essential Component Toward Standardized<i>In Vitro</i>Aerosol Exposure of Tobacco and Next Generation Nicotine Delivery Products

Characterization of a Vitrocell VC1 Using Nicotine Dosimetry: An Essential Component Toward StandardizedIn VitroAerosol Exposure of Tobacco and Next Generation Nicotine Delivery Products