Open AccessCharacterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals
Author(s) -
Maho Sasaki,
Tomohiro Kotaki,
Siti Qamariyah Khairunisa,
Shingo Tachibana,
Youdiil Ophinni,
Yoshitake Hayashi,
- Nasronudin,
Masanori Kameoka
Publication year - 2020
Publication title -
aids research and human retroviruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.993
H-Index - 92
eISSN - 1931-8405
pISSN - 0889-2229
DOI - 10.1089/aid.2019.0179
Subject(s) - virology , biology , virus , antibody , immune system , glycoprotein , antigen , gene , viral envelope , hiv vaccine , human immunodeficiency virus (hiv) , immunology , genetics , vaccine trial
To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and its characterization is necessary for vaccine development. The characterization of the transmitted/founder (T/F; i.e., recently infected) virus that is responsible for the establishment of infection and induction of primary anti-HIV-1 immune responses is important. We herein established HIV-1 env clones derived from recently infected Indonesian individuals. All env genes were classified into CRF01_AE. The immunological characterization of env clones was performed by neutralization tests using a series of broadly neutralizing antibodies. The present study is the first to immunologically characterize the CRF01_AE T/F virus circulating in Indonesia.