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S-Adenosyl-L-methionine (SAMe) is a dietary supplement commonly used to treat depression. SAMe facilitates dopamine and norepinephrine synthesis in the central nervous system. This study investigated the efficacy of SAMe for increasing tobacco abstinence among cigarette smokers.

S-Adenosyl-l-Methionine (SAMe) for Smoking Abstinence: A Randomized Clinical Trial