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We present a novel diffractive imaging method that harnesses a low-resolutionreal-space image to guide the phase retrieval. A computational algorithm isdeveloped to utilize such prior knowledge as a real-space constraint in theiterative phase retrieval procedure. Numerical simulations and proof-of-conceptexperiments are carried out, demonstrating our method's capability ofreconstructing high-resolution details that are otherwise inaccessible withtraditional phasing algorithms. With the present method, we formulate aconceptual design for the coherent imaging experiments at a next-generationX-ray light source.

Hybrid real- and reciprocal-space full-field imaging with coherent illumination