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Derivatives of 1,8-dioxoacridine and polyhydro-quinoline compounds are active compounds that have several beneficial bioactivities. The purpose of this research is to synthesize 1,8-dioxoacridine and polyhydro-quinoline derivatives supported by SiO 2 -AA-Glu as the catalyst and test their antioxidant activity. The reaction was conducted at the optimum condition with ethanol solvent at boiling point temperature (78 °C) for 60 min with a catalyst concentration of 3 % mol with a yield of 88.16 %. Analysis of formation products was confirmed using FTIR, UV-Vis Spectrophotometer, and GC-MS. The results of the analysis produced three 1,8-dioxoacridine and polyhydro-quinoline derivatives, namely 3,3,6,6-tetramethyl-9-phenyl-3,4,6,7,9,10-hexahydro-2H,5H-acridine-1,8-dione (compound 1), 9-(4-hydroxy-phenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-2H,5H-acridine-1,8-dione (compound 2), and 7,7-dimethyl-5-oxo-4-phenyl-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (compound 3). Compound 2 shows the best activity as an antioxidant compared to the other two compounds with an IC 50  value of 83.72 ppm.

iop conference series. materials science and engineering

Utilization of monosodium glutamate (MSG) for the synthesis of 1,8-dioxoacridine and polyhydro-quinoline derivates with SiO2-AA-glutamate catalyst and antioxidant ability test