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Single nucleotide polymorphism (SNP) in the MC4R gene has been known to be associated with feed intake and growth performance. Our objective was to analyze the association of SNP g.880A&gt;G to birth weight (BW), weaning weight (WW), and 6-month body weight (MW) in F1 cross Dorper x Garut sheep. In forty-one F1 cross Dorper x Garut sheep with phenotypic records, genotyping based on SNP g.880A&gt;G was achieved using the direct-sequencing process. As a result, the homozygous AA genotype was absent in the samples. The frequency of the G allele (90%) was higher than the A allele (10%), followed by GG (80%) and AG (20%) genotypes. The population did not deviate from Hardy Weinberg Equilibrium (p &gt; 0.05) based on SNP g.880A&gt;G. The SNP g.880A&gt;G was significantly associated with MW but not significant in BW and WW. The GG genotype (32.33 ± 4.81 kg) was higher MW than the AG genotype (27.19 ± 1.86 kg). In conclusion, the findings suggested that SNP g.880A&gt;G of the MC4R gene could be used as a potential selection tool for high MW in F1 cross Dorper x Garut sheep.

The association of SNP g.880A/G with body weight in F1 cross Dorper x Garut sheep