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The application of antibiotics expanded-spectrum third-generation cephalosporin for the treatment of infectious diseases in hospitals is known contribute to increasing resistance due to the presence of the CTX-M gene in the bacteria producing ESBLs. This study was aimed to detect ESBLs, isolate phenotype and CTX-M genes on Escherichia coli and Klebsiella pneumoniae collected from H. Adam Malik Central Hospital. Phenotypes of the bacterial were detection using Vitek two compact, while the CTX-M genes were detection using polymerase chain reaction technique. The results showed that 85 (100%) isolates were ESBLs consisted of 41(48%) of Escherichia coli, and 44 (52%) of Klebsiella pneumoniae, respectively. CTX-M genes were detection in 62 (72.94%) of the isolates which 31 (36.47%) were Escherichia coli, and 31 (36.47%) of the isolates were Klebsiella pneumoniae, respectively. This study indicates the high prevalence of CTX-M genes in Escherichia coli and Klebsiella pneumoniea causing bacterial antibiotic resistance.

iop conference series. earth and environmental science

Phenotypic and molecular detection ofBLACTX-M gene extended-spectrum beta-lactamases inescherichia coliandklebsiella pneumoniaeof north sumatera isolates