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The denaturation dynamics of a long double-stranded DNA is studied by meansof a model of the Poland-Scheraga type. We note that the linking of the twostrands is a locally conserved quantity, hence we introduce local updates thatrespect this symmetry. Linking dissipation via untwist is allowed only at thetwo ends of the double strand. The result is a slow denaturation characterizedby two time scales that depend on the chain length $L$. In a regime up to afirst characteristic time $\tau_1\sim L^{2.15}$ the chain embodies anincreasing number of small bubbles. Then, in a second regime, bubbles coalesceand form entropic barriers that effectively trap residual double-strandedsegments within the chain, slowing down the relaxation to fully moltenconfigurations, which takes place at $\tau_2\sim L^3$. This scenario isdifferent from the picture in which the helical constraints are neglected.

Multiple timescales in a model for DNA denaturation dynamics