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Coded aperture imaging transcends planar imaging with conventionalcollimators in efficiency and Field of View (FoV). We present experimentalresults for the detection of 141keV and 122keV {\gamma}-photons emitted byuniformly extended 99mTc and 57Co hot-spots along with simulations of uniformlyand normally extended 99mTc hot-spots. These results prove that the method canbe used for intra-operative imaging of radio-traced sentinel nodes and thyroidremnants. The study is performed using a setup of two gamma cameras, eachconsisting of a coded-aperture (or mask) of Modified Uniformly Redundant Array(MURA) of rank 19 positioned on top of a CdTe detector. The detector pixelpitch is 350 {\mu}m and its active area is 4.4x4.4 cm2, while the mask elementsize is 1.7mm. The detectable photon energy ranges from 15 keV up to 200 keVwith an energy resolution of 3-4 keV FWHM. Triangulation is exploited toestimate the 3D spatial coordinates of the radioactive spots within the systemFoV. Two extended sources, with uniform distributed activity (11 and 24 mm indiameter, respectively), positioned at 16cm from the system and with 3cmdistance between their centers, can be resolved and localized with accuracybetter than 5%. The results indicate that the estimated positions of spatiallyextended sources lay within their volume size and that neighboring sources,even with a low level of radioactivity, such as 30 MBq, can be clearlydistinguished with counting time about 3 seconds

Imaging of Spatially Extended Hot Spots with Coded Apertures for Intra-operative Nuclear Medicine Applications