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The measurement of the time of flight of the two 511 keV gammas recorded incoincidence in a PET scanner provides an effective way of reducing the randombackground and therefore increases the scanner sensitivity, provided that thecoincidence resolving time (CRT) of the gammas is sufficiently good. The bestcommercial PET-TOF system today (based in LYSO crystals and digital SiPMs), isthe VEREOS of Philips, boasting a CRT of 316 ps (FWHM). In this paper wepresent a Monte Carlo investigation of the CRT performance of a PET scannerexploiting the scintillating properties of liquid xenon. We find that anexcellent CRT of 70 ps (depending on the PDE of the sensor) can be obtained ifthe scanner is instrumented with silicon photomultipliers (SiPMs) sensitive tothe ultraviolet light emitted by xenon. Alternatively, a CRT of 160 ps can beobtained instrumenting the scanner with (much cheaper) blue-sensitive SiPMscoated with a suitable wavelength shifter. These results show the excellenttime of flight capabilities of a PET device based in liquid xenon.

Investigation of the Coincidence Resolving Time performance of a PET scanner based on liquid xenon: A Monte Carlo study