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It is expected a progressive increase of the industrial processes that manufacture of intermediate (iNEPs) and end products incorporating ENMs (eNEPs) to bring about improved properties. Therefore, the assessment of occupational exposure to airborne NOAA will migrate, from the simple and well-controlled exposure scenarios in research laboratories and ENMs production plants using innovative production technologies, to much more complex exposure scenarios located around processes of manufacture of eNEPs that, in many cases, will be modified conventional production processes. Here will be discussed some of the typical challenging situations in the process of risk assessment of inhalation exposure to NOAA in Multi-Source Industrial Scenarios (MSIS), from the basis of the lessons learned when confronted to those scenarios in the frame of some European and Spanish research projects.This paper exploits the results of the research developed by projects SCAFFOLD and EHS Advance. Project SCAFFOLD received funding from the European Union's FP7 research and innovation programme, under grant agreement No. 280535. Project EHS Advance received funding from the Basque Government research programme (Etortek). The authors would also like to express their grateful to companies BOSTLAN (Bizkaia, Spain) and TECNAN (Navarra, Spain) for the support provided to carry out the exposure measurements in their respective facilities

journal of physics. conference series

Towards an optimal adaptation of exposure to NOAA assessment methodology in Multi-Source Industrial Scenarios (MSIS): the challenges and the decision-making process