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A radio-guided surgery technique exploiting $\beta^-$ emitters is underdevelopment. It aims at a higher target-to-background activity ratio implyingboth a smaller radiopharmaceutical activity and the possibility of extendingthe technique to cases with a large uptake of surrounding healthy organs. Suchtechnique requires a dedicated intraoperative probe detecting $\beta^-$radiation. A first prototype has been developed relying on the low density andhigh light yield of the diphenylbutadiene doped para-therphenyl organicscintillator. The scintillation light produced in a cylindrical crystal, 5 mmin diameter and 3 mm in height, is guided to a photo-multiplier tube by opticalfibres. The custom readout electronics is designed to optimize its usage interms of feedback to the surgeon, portability and remote monitoring of thesignal. Tests show that with a radiotracer activity comparable to thoseadministered for diagnostic purposes the developed probe can detect a 0.1 mlcancerous residual of meningioma in a few seconds.

Polycrystalline para-terphenyl scintillator adopted in a $\beta^-$ detecting probe for radio-guided surgery