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Diabetes mellitus (DM) is a chronic disease condition that causes multiple complications in various organs such as kidney, reproductive system, and liver. It is mainly characterized by high blood glucose, insulin secretion deficiency or insulin resistance. In conventional diabetes, medications of insulin production and increased insulin sensitivity usually cause undesirable side effects and lead to poor adherence and therapy failure. In addition to insulin and oral hypoglycemic agents, there are different healthy ways to treat diabetes. Nanoparticles (NPs) such as zinc oxide (ZnO) NPs, selenium (Se) NPs, magnesium oxide (MgO) NPs, Copper (Cu) NPs, and cerium oxide (CeO2) NPs play an important role in controlling diabetes. The results reviewed here presented antidiabetic activity of CeO2 NPs, Se NPs, ZnO NPs, Cu NPs, and MgO NPs with fewer side effects when compared to antioxidant enzymes, glucose use, or increased insulin sensitivity, as these showed complications with diabetes.

A Review on nanoparticles as a promising approach to improving diabetes mellitus