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Rhenium-186 ( 186 Re) radioisotope has been suggested for palliative radiotherapy of bone metastic cancer patients and radiosynovectomy in nuclear medicine. Currently  186 Re has been mostly produced using neutron activation in nuclear reactors, whereas cyclotron-based production has not been well explored. In this paper, we theoretically propose cyclotron-based proton beams of up to 50 MeV for  186 Re production. By Employing the TALYS 2017 codes, we calculated nuclear cross-section for (p, n) nuclear reaction and then buit Matlab codes for the End-of-Bombardment (EOB) yield calculations of  186 W(p, n) 186 Re nuclear reaction while the predicted impurities were calculated for (p, 2n), (p, np), (p,α) and (p, d) nuclear reactions respectively. The TALYS calculated cross-sections indicated that the threshold energy for  186 W(p, n) 186 Re nuclear reaction is 8 MeV. The maximum calculated EOB yield for  186 W(p, n) 186 Re reaction at 50 MeV was 93.64 kBq/µAh which agreed with experimental data published elsewhere. The threshold energies for the (p,2n), (p, np), (p,α) and (p, d) were 7.58, 7.23, 2.0 and 4.99 MeV respectively. In addition, two radionuclides, i.e.  185 W and  183m Re as well as two stable isotopes, i.e.  185 Re and  184 W were predicted to be the main impurities in the  186 Re production. This study can be used as a reference for future  186 Re production when proton beams of up to 50 MeV are employed.

Cyclotron-based rhenium-186 production using proton beam of up to 50 MeV