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We have used the in vitro sircol collagen test to investigate the effects of Swietenia mahagoni seed extract on collagen production in human fibroblast cells (HSF1184). The results showed that Swietenia mahagoni seed extract with concentrations of 0.001, 0.01 and 0.1 mg / mL caused stimulation in the synthesis of type I collagen in HSF1184 cells. Although, three concentration of SC-CO2 and soxhlet that showed no statistically significant of collagen on the HSF1184 when compared with the negative control, while LA (fibroblast cells with pure Linoleic acid as supplement in culture medium) gave significant effect on the collagen production.

The effect of the swietenia mahagoni seed extracts on the production of collagen in human fibroblast cell (HSF1184)