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Microalgae is a phytoplankton that has antimicrobial activity. From 20 blue-green microalgae species, 78% have antibacterial activity and 42% antifungal activity, but there are still many other microalgae species that have unknown their activities. One of the microalgae whose unknown antimicrobial potential is  Spirulina plantentis . The purpose of this study was to determine the antimicrobial potential of autotrophic microalgae ( Spirulina plantentis ) which can be used as antimicrobial compounds from natural materials. This study used the agar diffusion method to see the antimicrobial activity of autotrophic microalgae. Microalgae suspension was tested their antimicrobial activities by using  Staphylococcus aureus ,  Escherichia coli , and  Candida albicans . The result shows that the MICs of  Spirulina plantentis  suspension against  C .  albicans ,  E .  coli  and  S .  aureus  were 62.5 ppm, 125 ppm and 500 ppm. The MBCs against  C .  albicans ,  E .  coli  and  S .  aureus  were 125 ppm, 250 ppm and 500 ppm. Antimicrobial activity of  Spirulina plantentis  suspension exhibited week against  C .  albicans  and  E .  coli , but no antimicrobial activity against  S. aureus. Spirulina plantentis  produced inhibition zone against  C .  albicans  by 3.9 mm at 125 ppm and 15.6 mm at 250 ppm, against  S .  aureus  and  E .  coli  by 1.4 mm at 500 ppm and 1.6 mm at 1000 ppm. Against  E .  coli  by 8.55 mm at 500 ppm and 12 mm at 1000 ppm.

Potential of Autotroph Microalgae (Spirulina plantentis) as Antimicrobial agent