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The directed motion of cell aggregates toward a chemical source occurs in&#13; many relevant biological processes. Understanding the mechanisms that&#13; control this complex behavior is of great relevance for our understanding&#13; of developmental biological processes and many diseases. In this paper,&#13; we consider a self-propelled particle model for the movement of heterogeneous&#13; subpopulations of chemically interacting cells towards an imposed stable chemical&#13; gradient. Our simulations show explicitly how self-organisation of cell populations &#13; (which could lead to engulfment or complete cell segregation) can arise from&#13; the heterogeneity of chemotactic responses alone. This new result complements&#13; current theoretical and experimental studies that emphasise the role of differential&#13; cell-cell adhesion on self-organisation and spatial structure of cellular aggregates.&#13; We also investigate how the speed of individual cell aggregations increases with the &#13; chemotactic sensitivity of the cells, and decreases with the number of cells inside the&#13; aggregates.

Modelling the collective response of heterogeneous cell populations to stationary gradients and chemical signal relay